It's another Number One issue for Bettie Page from David Avallone and Julius Ohta. And yes, it's continuing the Lovecraftian tale of Secret Agent Bettie Page, who stands against the elder gods and ancient aliens, but it's a new chapter, a new theme, and thus deserving of a new starting point. (Really, the BETTIE PAGE books have all just been standalone reads of a larger arc anyway.)
BETTIE PAGE UNBOUND is something altogether different. That is, it continues the ongoing adventure of Bettie and friends trying to stop Cthulhu and Nyarlathotep from entering our realm, but this time the creative team has an entirely new angle: a dimension-hopping Bettie who winds up in the form of a different adventurer with each hop. In this issue, she's Bettie the Page, chain-mail bikini warrior of Hyperborea.
Yes, Hyperborea. Bettie is a bad-ass, sword-wielding warrior, aka Red Sonja, a property currently under license to Dynamite.